853680-76-9

Usage

Uses

Used in Biological Research:
4-chloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine is used as a fluorescent lipid probe for visualizing lipid trafficking in cell membranes. Its high photostability and retention in cell membranes make it a valuable tool for studying membrane dynamics and functions in living cells.
Used in Medical Research:
In the medical research industry, 4-chloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine is used as a fluorescent lipid probe to track and label cell membranes, aiding in the investigation of various cellular processes and potential therapeutic targets. Its selective labeling of cellular membranes contributes to a better understanding of membrane-related diseases and the development of treatments.

InChI:InChI=1/C14H14ClN3O/c1-19-11-4-2-10(3-5-11)8-18-7-6-12-13(15)16-9-17-14(12)18/h2-5,9H,6-8H2,1H3

Upstream product

• 853680-74-7 2-(4,6-dichloropyrimidin-5-yl)ethanol 
• 2393-23-9 4-methoxy-benzylamine 
• 1553981-94-4 2-{4-chloro-6-[(4-methoxybenzyl)amino]pyrimidin-5-yl}ethanol 
• 1553981-96-6 6-chloro-5-(2-chloroethyl)-N-(4-methoxybenzyl)pyrimidin-4-amine 
• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 
• 171096-33-6 methyl 2-(4,6-dichloropyrimidin-5-yl)acetate 
• 853680-75-8 methanesulfonic acid 2-(4,6-dichloro-pyrimidin-5-yl)-ethyl ester 

Downstream Products

• 853680-77-0 4-[7-(4-methoxy-benzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS

The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.