853680-74-7

Usage

Uses

Due to the lack of comprehensive information on the uses of 2-(4,6-Dichloropyrimidin-5-yl)ethanol, it is not possible to provide a detailed list of its applications. However, based on its chemical structure and classification as a pyrimidine derivative, it can be inferred that 2-(4,6-Dichloropyrimidin-5-yl)ethanol may have potential applications in various industries, such as pharmaceuticals, agrochemicals, or materials science. Further research and development would be required to explore and confirm its specific uses and benefits in these fields.

Upstream product

• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 
• 171096-33-6 methyl 2-(4,6-dichloropyrimidin-5-yl)acetate 
• 16019-33-3 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde 

Downstream Products

• 1578264-09-1 C₁₄H₁₅Cl₂N₃O 
• 16372-08-0 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 
• 1578265-15-2 C₁₇H₁₅FN₄O₃ 
• 1578265-14-1 C₁₇H₁₅FN₄O₃ 
• 875251-47-1 2-(pyrimidin-5-yl)ethan-1-ol 
• 853680-77-0 4-[7-(4-methoxy-benzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 853680-76-9 4-chloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Preparation method of 5-(2-bromoethyl)pyrimidine

The invention discloses a preparation method of 5-(2-bromoethyl) pyrimidine, and belongs to the field of medicinal chemistry. 5-acetaldehydeyl-4,6-dichloropyrimidine, sodium borohydride and thionyl bromide which are used as raw materials undergo a three-step reaction under the action of a catalyst Pd/C to obtain the target product 5-(2-bromoethyl)pyrimidine. The method has the advantages of simplicity in operation, mild reaction conditions, and environmental friendliness, makes the comprehensive yield reach 80% or above, and is suitable for industrial large-scale production.

1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biological activity and physical properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight. Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating luteinizing hormone (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days.

Heteroaryl compounds useful as inhibitors of E1 activating enzymes

This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.