853685-35-5 Usage
Heterocyclic compound
A compound containing a ring structure with both carbon and non-carbon atoms, such as nitrogen (N) and oxygen (O) in this case This contributes to the compound's unique chemical properties and reactivity.
Pyrrolopyridine core structure
A core structure consisting of a pyrrole ring fused to a pyridine ring This structure is commonly found in pharmaceuticals and biologically active compounds, contributing to the compound's potential therapeutic applications.
Potential kinase inhibitor
The compound is known for its ability to inhibit kinases, which are enzymes involved in cellular processes such as cell growth and signaling This makes it a promising candidate for cancer treatment, as kinases are often dysregulated in cancer cells.
Neuroprotective agent
1H-pyrrolo[3,2-b]pyridine-2-carboxamide has been studied for its potential to protect neurons from damage or degeneration This could have implications for the treatment of neurodegenerative diseases, such as Alzheimer's or Parkinson's.
Component in the synthesis of various organic compounds
The compound can be used as a building block or intermediate in the synthesis of other organic compounds This makes it a valuable tool in the field of organic chemistry and drug discovery.
Versatile and valuable in medicinal chemistry and drug discovery
The unique structure and properties of 1H-pyrrolo[3,2-b]pyridine-2-carboxamide make it an important compound for further research and development in the creation of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 853685-35-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,3,6,8 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 853685-35:
(8*8)+(7*5)+(6*3)+(5*6)+(4*8)+(3*5)+(2*3)+(1*5)=205
205 % 10 = 5
So 853685-35-5 is a valid CAS Registry Number.
853685-35-5Relevant academic research and scientific papers
Huang, Bao-Guo,Kubiak, Gregory,Shay, John J.,Pemberton, Clive,Peers, James,Hanna, Reda G.,Powers, Matthew R.,Gamboa, Juan A.,Gelormini, Ann M.,Yarabe, Hyacinthe,Rudisill, Duane E.
, p. 1040 - 1045 (2011)
The development of a scalable process for 3-arylsulfanyl-1H-pyrrolo[3,2- bpyridine-2-carboxylic acid amides (1), potent casein kinase I inhibitors, is described. The rapid identification of suitable reaction conditions expedited the lab scale synthesis of drug substances for early toxicological evaluations. Further improvements were made to achieve a safe and cost-effective process to meet increasing demands for drug substances to support clinical studies. This paper describes the synthesis at multikilogram scale.
