853796-39-1

Basic information

• Product Name: 4-Bromo-2-methyl-benzeneacetic acid
• Synonyms: 4-Bromo-2-methyl-benzeneacetic acid;4-bromo-2-methylphenylacetic acid
• CAS NO: 853796-39-1
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.08
• Mol File: 853796-39-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 343.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.533±0.06 g/cm3(Predicted)
• PKA: 4.17±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-2-methyl-benzeneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-methyl-benzeneacetic acid(853796-39-1)
• EPA Substance Registry System: 4-Bromo-2-methyl-benzeneacetic acid(853796-39-1)

Safety Data

• Hazardous Substances Data: 853796-39-1(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-methyl-benzeneacetic acid, also known as bromoacetamidomethylbenzoic acid, is a chemical compound with the molecular formula C9H9BrO2. It is an organic compound that contains a bromine atom and a methyl group attached to a benzene ring. This chemical is commonly used in the synthesis of pharmaceutical drugs and is also known for its antibacterial and antifungal properties. It is a white to off-white crystalline powder that is soluble in organic solvents but insoluble in water. 4-Bromo-2-methyl-benzeneacetic acid is a versatile compound that has applications in the pharmaceutical, agricultural, and research industries.

Upstream product

• 68837-59-2 4-bromo-2-methylbenzoic acid 
• 17100-58-2 4-bromo-2-methylbenzyl alcohol 
• 24078-15-7 4-bromo-1-(chloromethyl)-2-methylbenzene 
• 215800-05-8 2-(4-bromo-2-methylphenyl)acetonitrile 
• 1037088-26-8 1-allyl-4-bromo-2-methylbenzene 
• 116632-39-4 2-methyl-4-bromoiodobenzene 
• 15852-73-0 (3-Bromophenyl)methanol 

Downstream Products

• 1037082-19-1 (R)-(4-(1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-3-methylphenyl)boronic acid 
• 1037082-18-0 (R)-(2-(4-bromo-2-methylphenyl)propoxy)(tert-butyl)dimethylsilane 
• 1037082-12-4 (R)-2-(4-bromo-2-methylphenyl)propan-1-ol 
• 958646-47-4 (4-bromo-2-methylphenyl)acetic acid methyl ester 
• 1415960-54-1 methyl 2-(2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate 

Relevant articles and documents

Aromatic Claisen Rearrangements of Benzyl Ketene Acetals: Conversion of Benzylic Alcohols to (ortho-Tolyl)acetates

Claisen rearrangements of benzyl vinyl ethers are much less facile than those of aliphatic allyl vinyl ethers, and their synthetic utility has remained relatively unexplored. A one-pot procedure is reported for the generation and Claisen rearrangement of benzyl vinyl ethers that contain an activating α-alkoxy substituent on the vinyl group. A [3,3]-sigmatropic mechanism was supported by trapping of the intermediate isotoluene in an intramolecular Alder–ene reaction.

SERINE/THREONINE KINASE INHIBITORS

Compounds having the formula I wherein R1, R2, R3, R4, R5, Ra, Rb, Rc, Rd, Re, n, r, s and t are as defined herein and which compounds are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.

C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.