853807-55-3Relevant academic research and scientific papers
Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds
Brabec, Viktor,Clarkson, Guy J.,Coverdale, James P. C.,Kostrhunova, Hana,Phillips, Roger M.,Postings, Miles,Rogers, Nicola J.,Scott, Peter,Shepherd, Samantha L.,Song, Hualong
, p. 6392 - 6395 (2020)
Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(ii)- and Zn(ii)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cel
SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF
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, (2018/08/03)
Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.
PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION
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, (2016/08/23)
Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.
'Click' ligand for 'click' chemistry: (1-(4-methoxybenzyl)-1-H-1,2,3-triazol-4-yl)methanol (MBHTM) accelerated copper-catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) at low catalyst loading
Tale, Rajesh H.,Gopula, Venkatesh B.,Toradmal, Gopal K.
supporting information, p. 5864 - 5869 (2015/11/02)
Readily accessible, cost effective, remarkably stable and easily tunable 1,2,3-triazole based ligand, (1-(4-methoxybenzyl)-1-H-1,2,3-triazol-4-yl)methanol (MBHTM) synthesized itself by 'click' chemistry shown to promote the dramatic rate enhancement of co
Novel phosphinite and phosphonite copper(I) complexes: Efficient catalysts for click azide-alkyne cycloaddition reactions
Lal, Steven,McNally, Jayne,White, Andrew J. P.,Diez-Gonzalez, Silvia
experimental part, p. 6225 - 6232 (2012/01/12)
The preparation of novel phosphinite- and phosphonite-bearing copper(I) complexes of the general formula [CuX(L)] is reported. These compounds, which remain scarce in the literature, could be prepared using readily available starting materials and were spectroscopically and structurally characterized. These complexes, together with their known phosphine and phosphite analogues, were then applied to the 1,3-dipolar cycloaddition of azides and alkynes, to find that the new complexes displayed the best activities. Full optimization of the reaction conditions resulted in a noteworthy Click catalytic system, active under very mild reaction conditions in the absence of any additive and using low metal loadings.
AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α
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Page/Page column 111, (2010/08/05)
Disclosed are compounds of the formula: (I) And pharmaceutically acceptable salts thereof, wherein the variables are as defined herein, which are useful in activating PP ARa and in treating atherosclerosis hypercholesterolemia, primary hypercholesterolemi
