85385-44-0

Upstream product

• 4067-80-5 2-bromo-2-deuteriopropane 
• 66107-29-7 4-methoxyphenyl triflate 
• 4132-48-3 1-methoxy-4-(1-methylethyl)benzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 114165-54-7 p-toluenesulfonic-2-d-isopropyl ester 
• 6274-50-6 methyl 2-(4-methoxyphenyl)-2-methylpropanoate 

Relevant academic research and scientific papers

Method for selective deuteration of benzyl-position carbon hydrogen bond of aromatic ring

The invention discloses a method for selective deuteration of benzyl-position carbon hydrogen bonds of aromatic rings. To the method, η is carried out on an aromatic ring by using a metal rhodium catalyst. 6 The coordination is activated so tha

Terminal-Selective Functionalization of Alkyl Chains by Regioconvergent Cross-Coupling

Hydrocarbons are still the most important precursors of functionalized organic molecules, which has stirred interest in the discovery of new C?H bond functionalization methods. We describe herein a new step-economical approach that enables C?C bonds to be constructed at the terminal position of linear alkanes. First, we show that secondary alkyl bromides can undergo in situ conversion into alkyl zinc bromides and regioconvergent Negishi coupling with aryl or alkenyl triflates. The use of a suitable phosphine ligand favoring Pd migration enabled the selective formation of the linear cross-coupling product. Subsequently, mixtures of secondary alkyl bromides were prepared from linear alkanes by standard bromination, and regioconvergent cross-coupling then provided access to the corresponding linear arylation product in only two steps.

DEUTERATED AMLEXANOX

Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods of producing deuterated amlexanox, and uses of deuterated amlexanox.