853891-71-1Relevant academic research and scientific papers
3. 6 - Disubstituted [1, 2, 4] triazolo [3, 4 - b] [1, 3, 4] thiadiazole compound and use thereof
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Paragraph 0052; 0060; 0071, (2018/11/22)
The invention discloses 3,6-disubstituted[1,2,4]triazolyl[3,4-b][1,3,4]thiadiazole compounds represented by general formula (I), and pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof. The compounds can be used as a transpeptidase SrtA inhibitor of Staphylococcus aureus, Bacillus pyogenes, Bacillus anthracis, Streptococcus pneumoniae and other Gram-positive bacteria, and can be used to prepare drugs for treating pathogen infection diseases with the transpeptidase SrtA of the Gram-positive bacteria, such as Staphylococcus aureus, Bacillus pyogenes, Bacillus anthracis and Streptococcus pneumoniae as target. The compounds avoid selection pressure induced drug resistance of pathogens to a certain degree, and mitigate threat of continuous drug-resistant pathogens to the health of human.
Metal-organic coordination architectures of condensed heterocyclic based 1,2,4-triazole: Syntheses, structures and emission properties
Wang, Duo-Zhi,Zhang, Qin,Zhang, Jian-Bin,Wu, Yuan-Gao,Cao, Ling-Hua,Ma, Peng-Yuan
experimental part, p. 216 - 226 (2012/09/21)
In efforts to explore the effects of metal ions, ligand structures, counteranions on the structures and properties of metal-organic complexes, seven d10 metals (Zn and Cd) and transition metals (Cu and Co) coordination compounds with condensed
