78027-00-6

Basic information

• Product Name: 4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL
• Synonyms: 4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL;AKOS BBS-00000461;ASISCHEM D13316
• CAS NO: 78027-00-6
• Molecular Formula: C₇H₇N₅S
• Molecular Weight: 193.23
• Mol File: 78027-00-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 338.9°C at 760 mmHg
• Flash Point: 158.7°C
• Appearance: /
• Density: 1.62g/cm³
• Vapor Pressure: 9.55E-05mmHg at 25°C
• Refractive Index: 1.829
• CAS DataBase Reference: 4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL(78027-00-6)
• EPA Substance Registry System: 4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL(78027-00-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 78027-00-6(Hazardous Substances Data)

Usage

General Description

4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL is a chemical compound with a complex structure consisting of a pyridine ring, a triazole ring, and a thiol group. It is a heterocyclic organic compound with potential applications in pharmaceutical and agrochemical industries. The compound is known for its ability to act as a chelating agent and can form coordination complexes with various metal ions. It has shown potential as a corrosion inhibitor and has been studied for its antimicrobial and antifungal properties. Additionally, 4-AMINO-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL has been investigated for its potential use in the development of new materials and as a fluorescent probe in bioimaging applications.

InChI:InChI=1/C7H7N5S/c8-12-6(10-11-7(12)13)5-2-1-3-9-4-5/h1-4H,8H2,(H,11,13)

Upstream product

• 75-15-0 carbon disulfide 
• 553-53-7 Nicotinic acid hydrazide 
• 59-67-6 nicotinic acid 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 3690-46-8 5-(pyridin-3''-yl)-1,3,4-oxadiazole-2(3H)-thione 
• 88317-41-3 potassium N-(pyridine-4-carbonyl)-hydrazine carbodithiolate 
• 3690-46-8 5-(3-pyridinyl)-1,3,4-oxadiazol-2-thiol 

Downstream Products

• 89814-06-2 4-{[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-pyridin-3-yl-4H-[1,2,4]triazole-3-thiol 
• 332943-03-0 5-(benzylthio)-3-(3-pyridyl)-4-amino-1,2,4-triazole 
• 488135-93-9 4-{[1H-indol-3-ylmethylene]amino}-5-pyridin-3-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1021323-90-9 4-(4-chlorobenzylideneamino)-5-(pyridin-3-yl)-2,4-dihydro-[1,2,4]-triazole-3-thione 
• 89814-09-5 4-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-5-pyridin-3-yl-4H-[1,2,4]triazole-3-thiol 
• 89814-04-0 2-{[(E)-3-Mercapto-5-pyridin-3-yl-[1,2,4]triazol-4-ylimino]-methyl}-phenol 
• 89814-08-4 4-{[1-(4-methoxyphenyl)methylidene]amino}-5-(3-pyridyl)-4H-1,2,4-triazol-3-yl-hydrosulfide 
• 89814-05-1 4-{[(E)-3-Mercapto-5-pyridin-3-yl-[1,2,4]triazol-4-ylimino]-methyl}-phenol 
• 89814-11-9 4-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-5-pyridin-3-yl-4H-[1,2,4]triazole-3-thiol 
• 89814-07-3 4-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-pyridin-3-yl-4H-[1,2,4]triazole-3-thiol 

Relevant articles and documents

An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives

Aldose reductase (AR) is a key enzyme, which triggers the excessive accumulation of sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular complications. Substantial evidence has proven that AR inhibition is a well-establ

Synthesis and biological evaluation of novel glycosyl-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives as acetylcholinesterase inhibitors

An efficient protocol for the synthesis of novel glycosyl-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives starting from the commercially available d-glucosamine hydrochloride is described by reaction of glycosyl isothiocyanate with various aminotriazoles in DMF. Glycosyl isothiocyanate is an important intermediate and synthetic methods are discussed. The acetylcholinesterase inhibitory activity of these compounds was tested by Ellman’s method. It was found that most compounds exhibited over 90% inhibition and they were subsequently evaluated for their IC50values.

Synthesis and biological evaluation of new Mannich and Schiff bases containing 1,2,4-triazole and 1,3,4-oxadiazole nucleus

5-(Pyridine-3-yl)-1,3,4-oxadiazole-2-thiole 2, obtaining starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases (3a–c) by the reaction with several heterocyclic amines in the presence of formaldehyde. 1,2,4-Triazole-3-thi