853893-95-5

Upstream product

• 853893-93-3 (2S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxoimidazolidin-1-yl}butanoic Acid 
• 169280-56-2 4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide 
• 853894-11-8 tert-butyl (2-hydroxyethyl)[(2-methyl-1,3-thiazol-4-yl)methyl]carbamate 
• 853894-12-9 Methyl (2S)-3-methyl-2-[(2-{[(2-methyl-1,3-thiazol-4-yl)methyl]amino}ethyl)amino]butanoate 
• 853894-15-2 (S)-3-Methyl-2-[3-(2-methyl-thiazol-4-ylmethyl)-2-oxo-imidazolidin-1-yl]-butyric acid methyl ester 
• 853894-14-1 2-{2-[tert-butoxycarbonyl-(2-methyl-thiazol-4-ylmethyl)-amino]-ethylamino}-3-methyl-butyric acid methyl ester 
• 39238-07-8 4-(chloromethyl)-2-methyl-1,3-thiazole 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 853894-13-0 2-{[(2-methyl-1,3-thiazol-4-yl)methyl]amino}ethanol 
• 183004-94-6 3-S-(N-tert-butyloxyformamido)-[2R-hydroxy-1-[(4-aminophenylsulfonyl)(2-methylpropyl)]amino]-4-phenylbutane 
• 191226-98-9 [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Oximinoarylsulfonamides as potent HIV protease inhibitors

The need for a potent HIV protease inhibitor (PI) to combat emerging PI-resistant viruses is anticipated. Analogs formulated from the combination of structural fragments of Ritonavir, Lopinavir, and Amprenavir were synthesized. Analogs containing the oxime pharmacophore were found to have improved activities against both wild type and resistant (A17) viruses. The synthesis and structure-activity relationships (SAR) based upon the in vitro IC50 of this series of compounds are reported.