853902-12-2Relevant academic research and scientific papers
Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3-Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams
Chen, Jie,Huang, Bao-Qin,Wang, Zeng-Qing,Zhang, Xue-Jing,Yan, Ming
supporting information, p. 9742 - 9746 (2019/11/28)
An enantioselective conjugate addition of ethylene sulfonyl fluorides to 3-amido-2-oxindoles has been developed. Quinine-derived squaramides were identified as efficient catalysts. A series of spirocyclic oxindole sultams were prepared with excellent yields and enantioselectivities. A reaction mechanism via bifunctional activation was proposed.
Glycosides of hydroxylamine derivatives: I. Phase transfer synthesis and the study of the influence of glucosaminides of isatine 3-oximes on bacterial luminescence
Kuryanov,Chupakhina,Shapovalova,Katsev,Chirva
body text, p. 231 - 239 (2012/05/20)
Easily deprotoned hydroxyl groups of isatine 3-oximes were glycosylated in high yields by α-D-glucosaminyl chloride peracetate in the solid potassium carbonate-acetonitrile phase transfer system. It was found that catalytic amounts of 15-crown-5 supported
Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors
Cao, Jingrong,Gao, Huai,Bemis, Guy,Salituro, Francesco,Ledeboer, Mark,Harrington, Edmund,Wilke, Susanne,Taslimi, Paul,Pazhanisamy,Xie, Xiaoling,Jacobs, Marc,Green, Jeremy
scheme or table, p. 2891 - 2895 (2010/01/16)
A series of N-benzylated isatin oximes were developed as inhibitors of the mitogen-activated kinase, JNK3. X-ray crystallographic structures aided in the design and synthesis of novel, selective compounds, that inhibit JNK3, but not p38 MAP kinase and provided key insights into understanding the behavior of gatekeeper residue methionine-146 in determining target selectivity for this series.
