853934-99-3Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of novel coumarin derivatives
Al-Awad, Sanaryh Mohammed,Jaccob, Ausama Ayob,Raheem, Leaqaa Abdalredha
, p. 865 - 874 (2020/02/25)
The current work focuses on new architecture, synthesis of coumarin-oxadiazole hybrid derivative products as both these (coumarin ring and oxa-diazole) have a wide variety of biological behavior, Compounds containing the nucleus of coumarin (2H-1-benzopyran-2-one) are an interesting class of hetero cycles which hold an important role in the field of natural ingredients and synthetic organic chemistry. It has been exciting medicinal chemists to study native coumarins or synthetic analogs for their application for decades. And they can be further modified to synthesize more effective and potent drugs. Compounds have been characterized by spectrophotometry of physicochemical properties and their structures verified by infrared spectroscopy (FTIR) and nuclear magnetic resonance (1H-NMR) Such new derivatives of coumarinyl-oxadiazole was qualified to estimate the lethal dose, anticancer, anticoagulant and antioxidant activity. Their pharmacological properties depend on their pattern of substitution, compound S4F proved significant anticoagulant activity in concentration (50, 100, 200 mg/ml) similar for heparin, and monitor the coagulation effect on plasma, while compound S4 CO give significant anticancer activity against MCF-7 a breast cancer cell. Spe-cific compounds have strong antioxidants with the effective action of radical scavengers; the S4Cl compound with IC50 1.49 is the most potent antioxidant activity note. Basically, all the formulations tested reported satisfactory behavior. The review shows that varieties of coumarin derivatives have synthesized and shown anti-cancer, antioxidant and anti-coagulant potentials. These derivatives synthesis and its biological assay can be further modified in the future to improve the anti-cancer, anti-oxidant and anticoagulant potentials of the versatile coumarin nucleus.
Synthesis, characterisation and anthelmintic activity of 3-(4-acetyl-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2H-chromen-2-one derivatives
Naga Sudha,Sridhar,Girija Sastry,Reddy,Sreevidya, Owk,Lavanya,Asha Jyothi,Nagesh,Sen, Saikat,Chakraborty, Raja
, p. 422 - 427 (2013/05/08)
Convectional synthesis of several coumarin-oxadiazole derivatives from starting compounds 2-hydroxy benzaldehyde and diethylmalonate has been accomplished. Successful synthesis of the derivatives has been confirmed by spectral studies i.e. UV, IR, MS and 1H NMR. All successfully synthesized compounds have been screened for in vitro anthelmintic activity by taking adult Indian earthworms Pheretima posthuma. Among all the derivatives 4-chloro derivatives have shown maximum activity when compared with the standard.
Synthesis of novel 3-(4-acetyl-5H/methyl-5-substituted phenyl-4,5-dihydro- 1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones as potential anticonvulsant agents
Bhat, Mashooq A.,Siddiqui, Nadeem,Khan, Suroor A.
experimental part, p. 235 - 239 (2009/04/04)
A series of 3-(4-acetyl-5H/methyl-5-substituted phenyl-4,5-dihydro-1,3,4- oxadiazol-2-yl)-2H-chromene-2-ones (6a-j) were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. A majority of the compounds was active in MES tests. Compound (6e) was found to be potent and had activity at lower dose of 30 mg/kg in MES-test. All the compounds were less toxic as compared with the standard drug phenytoin.
