853995-65-0Relevant academic research and scientific papers
A rapid and convenient synthesis of novel 1-imino-2,3-dihydro-1H- pyrazino[2,1,-b]quinazolin-5-ones
Pereira, Maria De Fatima,Alexandre, Fran?ois René,Thiéry, Valérie,Besson, Thierry
, p. 3097 - 3099 (2004)
Exploring original approaches for the synthesis of therapeutic agents having a quinazoline part, we discovered that novel 3,4-dihydro-2H-pyrazino[2,1, -b]quinazolines (3) may be rapidly and easily obtained via the chemistry of 4,5-dichloro-1,2,3-dithiazol
A short synthesis of quinazolinocarboline alkaloids rutaecarpine, hortiacine, euxylophoricine A and euxylophoricine D from methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)anthranilates
Mohanta, Pramod K.,Kim, Kyongtae
, p. 3993 - 3996 (2007/10/03)
Reactions of methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)anthranilates with tryptamine at room temperature produced 2-cyano-3-[2-(indol-3-yl)ethyl]-4(3H)-quinazolinones, which underwent cyclization on heating with TFAA/HCl(g) to afford quinazolinocarboline alkaloids rutaecarpine (1a), hortiacine (1b), euxylophoricine A (1c) and euxylophoricine D (1d) in excellent yields.
