853997-34-9Relevant academic research and scientific papers
Secretory phospholipase A2 hydrolysis of phospholipid analogues is dependent on water accessibility to the active site
Peters, Guenther H.,Moller, Martin S.,Jorgensen, Kent,Roennholm, Petra,Mikkelsen, Mette,Andresen, Thomas L.
, p. 5451 - 5461 (2007)
A new and unnatural type of phospholipids with the head group attached to the 2-position of the glycerol backbone has been synthesized and shown to be a good substrate for secretory phospholipase A2 (sPLA2). To investigate the unexpe
LIPID-BASED DRUG DELIVERY SYSTEMS CONTAINING UNNATURAL PHOSPHOLIPASE A2 DEGRADABLE LIPID DERIVATIVES AND THE THERAPEUTIC USES THEREOF
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Page/Page column 5-6; 49-50; 2/7, (2008/06/13)
The present invention relates to a lipid-based drug delivery system for administra-tion of a lysolipid derivative present in a prodrug from, said prodrug furthermore being a substrate for extracellular phospholipase A2 to the extent that an organic radi-c
