854018-77-2Relevant academic research and scientific papers
Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981
Luker, Tim,Bonnert, Roger,Brough, Steve,Cook, Anthony R.,Dickinson, Mark R.,Dougall, Iain,Logan, Chris,Mohammeda, Rukhsana T.,Paine, Stuart,Sanganee, Hitesh J.,Sargent, Carol,Schmidt, Jerzy A.,Teague, Simon,Thom, Stephen
scheme or table, p. 6288 - 6292 (2011/11/29)
Novel indole-3-thio-, 3-sulfonyl- and 3-oxy-aryl-1-acetic acids are reported which are potent, selective antagonists of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2). Optimization required maintenance of high
1-ACETIC ACID-INDOLE, -INDAZOLE AND-BENZIMIDAZOLE DERIVATIVES USFUL FOR THE TREATMENT OF RESPIRATORY DISORDERS
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Page/Page column 29, (2008/06/13)
The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders.
