854044-30-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-Cyano-1H-pyrrole-2-carboxylic acid is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, leveraging its structural versatility and reactivity to contribute to the development of new and effective compounds.
Used in Organic Synthesis:
As a building block in organic synthesis, 5-Cyano-1H-pyrrole-2-carboxylic acid is utilized for its potential to create a wide range of chemical structures, which can be applied across different fields of chemistry.
Used in Therapeutic Applications:
5-Cyano-1H-pyrrole-2-carboxylic acid is being investigated for its potential therapeutic properties, particularly as an anti-inflammatory and anti-cancer agent. Its application in this field is still under research, with the aim of understanding its full biological activities and developing it into a viable treatment option.

InChI:InChI=1/C6H4N2O2/c7-3-4-1-2-5(8-4)6(9)10/h1-2,8H,(H,9,10)

Upstream product

• 937-19-9 5-cyano-1H-pyrrole-2-carboxylic acid methyl ester 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 21635-99-4 ethyl 5-cyano-1H-pyrrole-2-carboxylate 

Downstream Products

• 1432283-27-6 5-cyano-N-(p-tolyl)-1H-pyrrole-2-carboxamide 
• 1432283-14-1 C₁₃H₁₂N₆O 

Relevant academic research and scientific papers

Dissecting the complex recognition interfaces of potent tetrazole- and pyrrole-based anion binders

Tetrazoles are potent anion binders. We report here a new family of tetrazole-pyrrole-amide hosts that arise when a tetrazole is incorporated as a new binding element alongside the well-known amidopyrrole anion-binding scaffold. In addition to reporting three new, modular synthetic routes that can be used to access these structures, we also report that the new hosts are highly potent binders of chloride. Along the way, we carried out studies of a pyrrole ester control compound that, surprisingly, bound anions almost as strongly as did the amide analogues. This led us to investigate further the relative importance of the amide NH in halide binding. We report that, despite the regular appearance of this close amide NH - -Cl contact in calculated and experimental X-ray structures, the amide NH in this family of anion hosts does not hydrogen bond strongly to chloride in solution.

C-fms kinase inhibitors

The invention is directed to compounds of Formulae I: wherein A, R1, R2, R3, R4, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.