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85407-08-5

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85407-08-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 85407-08-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,4,0 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 85407-08:
(7*8)+(6*5)+(5*4)+(4*0)+(3*7)+(2*0)+(1*8)=135
135 % 10 = 5
So 85407-08-5 is a valid CAS Registry Number.

85407-08-5Downstream Products

85407-08-5Relevant articles and documents

Synthesis and antiviral activity of distamycin A analogues: Substitutions on the different pyrrole nitrogens and in the amidine function

Grehn,Ragnarsson,Eriksson,Oberg

, p. 1042 - 1049 (2007/10/02)

Several new analogues of the antiviral antibiotic distamycin A were synthesized and assayed for their effects on influenza and herpes simplex virus. The new compounds 5b-j (R1-3 = H, CH3, and C2H5, R(4,5) = H and CH3) were obtained via stepwise prepared formylated trimeric benzyl 4-aminopyrrole-2-carboxylates 3a-h, which after catalytic hydrogenolysis were coupled as N-succinimidyl esters directly with the proper β-aminopropionamidine, unsubstituted or substituted with one or two methyl groups in the aminidine function. Most of the new analogues did not exhibit significant effects on the viruses studied, but three compounds (5f-h) displayed activity on herpes virus as demonstrated in plaque formation and virus yield assays. Elevated cytotoxicity was simultaneously observed for 5g and 5h. For compound 5f, a partial separation of antiherpes activity and cytotoxicity was accomplished. The differences in antiherpes activity did not correspond to the differences in the inhibition of herpes virus DNA polymerase.

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