854261-83-9

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 110192-19-3 7-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 43207-78-9 7-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 247132-78-1 benzyl 4-[2-(N,N'-di-tert-butoxycarbonylamidin)-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl]piperidine-1-carboxylate 
• 247132-77-0 N,N'-di-tert-butoxycarbonyl-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxamidine 
• 159275-17-9 benzyl 4-(bromomethyl)tetrahydro-1-(2H)-pyridinecarboxylate 
• 122860-33-7 benzyl 4-(hydroxymethyl)piperidine-N-carboxylate 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 247132-79-2 N,N'-di-tert-butoxycarbonyl-7-(piperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-carboxamidine 
• 30798-64-2 7-hydroxy-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 (JTV-803) exhibited potent inhibitory activity against FXa and good selectivity with respect to other serine proteases (thrombin, plasmin, and trypsin). In addition, compound 2 exhibited potent anti-FXa activity after intravenous and oral administration to cynomolgus monkey, and showed a dose-dependent antithrombotic effect in a rat model of venous thrombosis.

Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 exhibited potent inhibitory activity against factor Xa (FXa) and good selectivity with respect to other serine