85428-31-5

Basic information

• Product Name: Oxiranepropanoic acid, methyl ester, (2S)-
• Synonyms: Oxiranepropanoic acid, methyl ester, (2S)-;Oxiranepropanoic acid, methyl ester, (S)-
• CAS NO: 85428-31-5
• Molecular Formula: C6H10O3
• Molecular Weight: 130.144
• Mol File: 85428-31-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Oxiranepropanoic acid, methyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxiranepropanoic acid, methyl ester, (2S)-(85428-31-5)
• EPA Substance Registry System: Oxiranepropanoic acid, methyl ester, (2S)-(85428-31-5)

Safety Data

• Hazardous Substances Data: 85428-31-5(Hazardous Substances Data)

Upstream product

• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 

Downstream Products

• 58917-25-2 (R)-5-methyl-2-oxotetrahydrofuran 
• 864182-70-7 (4R)-2-(phenylselenyl)-6-methyl-8-(tert-butyldimethylsilyloxy)oct-6-en-4-olide 
• 864270-18-8 (3R)-4-methyl-3-[(5-methylene-2-phenyl-1,3-dioxan-4-yl)methyl]-1-{5-[(2E)-2-methyl-4-oxobut-2-enyl]-2-oxo-2,5-dihydrofuran-3-yl}pent-4-enyl acetate 
• 864270-15-5 (3R)-1-{5-[(2E)-4-hydroxy-2-methylbut-2-enyl]-2-oxo-2,5-dihydrofuran-3-yl}-4-methyl-3-[(5-methylene-2-phenyl-1,3-dioxan-4-yl)methyl]pent-4-enyl acetate 
• 864270-19-9 (E)-4-{(R)-4-[(R)-1-Acetoxy-4-methyl-3-(5-methylene-2-phenyl-[1,3]dioxan-4-ylmethyl)-pent-4-enyl]-5-oxo-2,5-dihydro-furan-2-yl}-3-methyl-but-2-enoic acid 
• 864182-80-9 (3R)-5-hydroxy-6-(hydroxymethyl)-3-isopropenyl-1-{5-[2-methyl-4-oxo-4-(phenylseleno)but-2-enyl]-2-oxo-2,5-dihydrofuran-3-yl}hept-6-enyl acetate 
• 864270-14-4 5-[(2E)-4-(tert-butyldimethylsilyloxy)-2-methylbut-2-enyl]-3-{(3S)-1-hydroxy-4-methyl-3-[(5-methylene-2-phenyl-1,3-dioxan-4-yl)methyl]pent-4-enyl}furan-2(5H)-one 
• 864270-16-6 (3R)-5-hydroxy-3-isopropenyl-6-{[(4-methoxybenzyl)oxy]methyl}-1-{5-[2-methyl-4-oxo-4-(phenylseleno)but-2-enyl]-2-oxo-2,5-dihydrofuran-3-yl}hept-6-enyl acetate 
• 864270-17-7 (3R)-1-{5-[(2E)-4-(tert-butyldimethylsilyloxy)-2-methylbut-2-enyl]-2-oxo-2,5-dihydrofuran-3-yl}-4-methyl-3-[(5-methylene-2-phenyl-1,3-dioxan-4-yl)methyl]pent-4-enyl acetate 
• 864270-13-3 5-[(2E)-4-(tert-butyldimethylsilyloxy)-2-methylbut-2-enyl]-3-{(3S)-1-hydroxy-4-methyl-3-[(5-methylene-2-phenyl-1,3-dioxan-4-yl)methyl]pent-4-enyl}-3-(phenylseleno)dihydrofuran-2(3H)-one 
• 161479-12-5 (4R)-4-(tert-butyldiphenylsilyloxymethyl)-4-thiobutyro-1,4-lactone 
• 127251-17-6 [(Z)-(S)-1-((E)-5-Bromo-pent-3-enyl)-non-3-enyloxy]-tert-butyl-diphenyl-silane 
• 122221-77-6 (2E,8Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,8-dienoic acid methyl ester 
• 122221-83-4 C₃₅H₄₄O₆ 

Relevant articles and documents

METHOD FOR SYNTHESIZING A PRECURSOR OF A SINGLE DAIRY-LACTONE ISOMER

This disclosure provides a method for preparing a precursor of a single dairy-lactone isomer, methods of preparing a single dairy-lactone isomer, and to the organoleptic uses thereof.

HETEROCYCLIC COMPOUNDS AND THEIR USE AS RETINOID-RELATED ORPHAN RECEPTOR (ROR) GAMMA-T INHIBITORS

Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Two approaches to the enantioselective synthesis of (4R)-(-)-4-hydroxymethyl-4-thiobutyro-1,4-lactone

Enantiomerically pure (4R)-4-hydroxymethyl-4-thiobutyro-1,4-lactone [(5R)-dihydro-5-(hydroxymethyl)-2(3H)-thiophenone (12)] and derivatives were synthesized by two enantiospecific sequences employing D-ribono-1,4-lactone (1) and L-glutamic acid (6) as chiral templates. The key step in the first approach was the SmI2-promoted 2,3-deoxygenation of a 4-thio-L-lyxono-1,4-lactone derivative, prepared from 1. The other strategy, which starts from 6, involves the (5S)-dihydro-5-(p-tolylsulfonyloxymethyl)-2-(3H)-furanone (8) as chiral precursor. This was converted into a 4,5-thiirane derivative via the corresponding 4,5-epoxide. Regioselective opening of the thiirane ring by acetate followed by O-deacetylation gave 12 (40% overall yield from 8). Copyright (C) 2000 Elsevier Science Ltd.