854300-34-8Relevant articles and documents
A new structural motif for μ-opioid antagonists
Van Den Eynde, Isabelle,Laus, Georges,Schiller, Peter W.,Kosson, Piotr,Chung, Nga N.,Lipkowski, Andrzej W.,Tourwé, Dirk
, p. 3644 - 3648 (2005)
On the basis of the structural features of the Dmt-Tic pharmacophore, a new motif leading to a fairly potent μ-opioid antagonist is described. This motif contains the 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-one skeleton as a substitute for the Tic resi