854300-80-4Relevant academic research and scientific papers
NUCLEOSIDE-LIPID CONJUGATES, THEIR METHOD OF PREPARATION AND USES THEREOF
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Example 1, (2008/06/13)
The invention provides methods for synthesizing nucleoside-lipid conjugates having varying fatty acid and alkyl chain lengths with or without unsaturation and their use in the treatment of cancer and viral diseases. More particularly, the invention provid
Synthesis and biological evaluation of gemcitabine-lipid conjugate (NEO6002)
Ali, Shoukath M.,Khan, Abdul R.,Ahmad, Moghis U.,Chen, Paul,Sheikh, Saifuddin,Ahmad, Imran
, p. 2571 - 2574 (2007/10/03)
A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar
