854392-02-2

Basic information

• Product Name: (3-chloro-benzyl)-methyl-(4-nitro-benzyl)-amine
• Synonyms: (3-chloro-benzyl)-methyl-(4-nitro-benzyl)-amine
• CAS NO: 854392-02-2
• Molecular Weight: 290.749
• Mol File: 854392-02-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3-chloro-benzyl)-methyl-(4-nitro-benzyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-chloro-benzyl)-methyl-(4-nitro-benzyl)-amine(854392-02-2)
• EPA Substance Registry System: (3-chloro-benzyl)-methyl-(4-nitro-benzyl)-amine(854392-02-2)

Safety Data

• Hazardous Substances Data: 854392-02-2(Hazardous Substances Data)

Upstream product

• 39191-07-6 3-chloro-N-methylbenzylamine 
• 100-14-1 4-nitrobenzyl chloride 

Downstream Products

• 52245-37-1 methyl-(4-nitro-benzyl)-carbamonitrile 
• 766-80-3 1-bromomethyl-3-chlorobenzene 

Relevant articles and documents

Substituted indolines which inhibit receptor tyrosine kinases

Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.

Indolinones having kinase inhibitory activity

The present invention relates to substituted indolinones of general formula [Figure] wherein R1 to R5, and X are defined as in claim 1, the isomers thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, particularly an inhibitory effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells, pharmaceutical compositions containing these (compounds, their use and processes for preparing them.