854443-23-5

Basic information

• Product Name: (S)-N-methoxy-N-methyl-2-benzyloxycarbonylamino-3-(4-benzyloxyphenyl)-propanoic amide
• Synonyms: (S)-N-methoxy-N-methyl-2-benzyloxycarbonylamino-3-(4-benzyloxyphenyl)-propanoic amide
• CAS NO: 854443-23-5
• Molecular Weight: 448.519
• Mol File: 854443-23-5.mol

Chemical Properties

• CAS DataBase Reference: (S)-N-methoxy-N-methyl-2-benzyloxycarbonylamino-3-(4-benzyloxyphenyl)-propanoic amide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-methoxy-N-methyl-2-benzyloxycarbonylamino-3-(4-benzyloxyphenyl)-propanoic amide(854443-23-5)
• EPA Substance Registry System: (S)-N-methoxy-N-methyl-2-benzyloxycarbonylamino-3-(4-benzyloxyphenyl)-propanoic amide(854443-23-5)

Safety Data

• Hazardous Substances Data: 854443-23-5(Hazardous Substances Data)

Upstream product

• 86827-18-1 N-benzyloxycarbonyl-O-benzyl-L-tyrosine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 

Downstream Products

• 854443-32-6 C₇₅H₉₃N₇O₁₁Si 
• 854443-31-5 [(1S,2S)-1-(2-{(S)-4-Allyloxycarbonylamino-1-[(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidine-1-carbonyl]-butylamino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid tert-butyl ester 
• 854443-29-1 α-[(4S,5S)-5-azido-6-(4-benzyloxyphenyl)-1,2-dihydroxy-hex-4-oxy]-acetic acid tert-butyl ester 
• 854443-25-7 [(S)-1-(4-Benzyloxy-benzyl)-2-hydroxy-pent-4-enyl]-carbamic acid benzyl ester 
• 854443-21-3 [(1S,2S)-2-azido-3-(4-benzyloxyphenyl)-1-(2-oxoethyl)-prop-1-oxy]-acetic acid tert-butyl ester 
• 854443-26-8 (4S,5S)-5-allyl-4-(4-benzyloxybenzyl)-oxazolidin-2-one 
• 854443-28-0 (2S,3S)-2-azido-1-(4-benzyloxyphenyl)-hex-5-en-3-ol 
• 854443-27-9 (2S,3S)-2-amino-1-(4-benzyloxyphenyl)-hex-5-en-3-ol 
• 854443-24-6 (S)-2-benzyloxycarbonylamino-1-(4-benzyloxyphenyl)-hex-5-en-3-one 

Relevant articles and documents

Synthesis of a β-turn mimetic suitable for incorporation in the peptide hormone LHRH

LHRH is a decapeptide hormone which plays a central role in neuroendocrinology. Conformational studies have suggested that LHRH may adopt a β-turn involving residues 5-8 when bound to its receptor. A β-turn mimetic with side chains corresponding to those of a Tyr-Gly-Leu-Orn tetrapeptide has therefore been synthesized for incorporation at positions 5-8 in LHRH. In the turn mimetic, residues i and i+1 are connected by a ψ[CH2O] isostere instead of an amide bond, while a covalent ethylene bridge replaces the hydrogen bond which is often found between residues i and i+3 in β-turns. The turn mimetic was assembled from three types of building blocks: an azido aldehyde, an Fmoc protected amino acid and a protected dipeptide amine.