854443-30-4

Basic information

• Product Name: N^δ-(allyloxycarbonyl)-N^α-(fluoren-9-ylmethoxycarbonyl)-L-ornithyl-O-(tert-butyldiphenylsilyl)-L-prolinol
• Synonyms: N^δ-(allyloxycarbonyl)-N^α-(fluoren-9-ylmethoxycarbonyl)-L-ornithyl-O-(tert-butyldiphenylsilyl)-L-prolinol
• CAS NO: 854443-30-4
• Molecular Weight: 760.018
• Mol File: 854443-30-4.mol

Chemical Properties

• CAS DataBase Reference: N^δ-(allyloxycarbonyl)-N^α-(fluoren-9-ylmethoxycarbonyl)-L-ornithyl-O-(tert-butyldiphenylsilyl)-L-prolinol(CAS DataBase Reference)
• NIST Chemistry Reference: N^δ-(allyloxycarbonyl)-N^α-(fluoren-9-ylmethoxycarbonyl)-L-ornithyl-O-(tert-butyldiphenylsilyl)-L-prolinol(854443-30-4)
• EPA Substance Registry System: N^δ-(allyloxycarbonyl)-N^α-(fluoren-9-ylmethoxycarbonyl)-L-ornithyl-O-(tert-butyldiphenylsilyl)-L-prolinol(854443-30-4)

Safety Data

• Hazardous Substances Data: 854443-30-4(Hazardous Substances Data)

Upstream product

• 209627-36-1 (2S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)idinepyrrol 
• 147290-11-7 N-fluoren-9-ylmethoxycarbonyl-N'-allyloxycarbonyl-ornithine 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 854443-22-4 N^δ-(allyloxycarbonyl)-L-ornithyl-O-(tert-butyldiphenylsilyl)-L-prolinol 
• 854443-31-5 [(1S,2S)-1-(2-{(S)-4-Allyloxycarbonylamino-1-[(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidine-1-carbonyl]-butylamino}-ethyl)-2-azido-3-(4-benzyloxy-phenyl)-propoxy]-acetic acid tert-butyl ester 
• 854443-32-6 C₇₅H₉₃N₇O₁₁Si 

Relevant articles and documents

Synthesis of a β-turn mimetic suitable for incorporation in the peptide hormone LHRH

LHRH is a decapeptide hormone which plays a central role in neuroendocrinology. Conformational studies have suggested that LHRH may adopt a β-turn involving residues 5-8 when bound to its receptor. A β-turn mimetic with side chains corresponding to those of a Tyr-Gly-Leu-Orn tetrapeptide has therefore been synthesized for incorporation at positions 5-8 in LHRH. In the turn mimetic, residues i and i+1 are connected by a ψ[CH2O] isostere instead of an amide bond, while a covalent ethylene bridge replaces the hydrogen bond which is often found between residues i and i+3 in β-turns. The turn mimetic was assembled from three types of building blocks: an azido aldehyde, an Fmoc protected amino acid and a protected dipeptide amine.