854497-57-7Relevant academic research and scientific papers
Stereoselective synthesis of enantioenriched acetylenic 1,2-amino alcohols
Chemla, Fabrice,Ferreira, Franck,Gaucher, Xavier,Palais, Laetitia
, p. 1235 - 1241 (2007)
The stereoselective synthesis of enantioenriched anti-and syn-4-aminoalk-1-yn-3-ols is described. Initial reaction of racemic 3-(methoxymethoxy)allenylzinc with enantiopure Ellman's (SS)-(tert- butylsulfinyl)imines was shown to give straightfor
O2-Assisted Four-Component Reaction of Vinyl Magnesium Bromide with Chiral N-tert-Butanesulfinyl Imines To Form syn-1,3-Amino Alcohols
Gao, Lu,Luo, Jingfan,Song, Zhenlei,Wang, Runping,Zhang, Hongyun,Zheng, Chunmei
supporting information, p. 24644 - 24649 (2021/10/12)
An O2-assisted, four-component reaction has been developed to synthesize a wide range of syn-1,3-amino alcohols in one step. The reaction proceeds by oxygenation of vinyl magnesium bromide (component-I) with O2 (component-II) to give
KHSO4-mediated condensation reactions of tert-butanesulfinamide with aldehydes. Preparation of tert-butanesulfinyl aldimines
Huang, Zhiyan,Zhang, Min,Wang, Yin,Qin, Yong
, p. 1334 - 1336 (2007/10/03)
Optically pure tert-butanesulfinyl aldimines 1 were prepared by direct condensation of chiral tert-butanesulfinamide 3 with aldehydes 2 in high yields in the presence of KHSO4. The main advantage of KHSO4 is that it is applicable to the condensation reactions of a variety of aldehydes, including electron deficient and electron rich (hetereo)aromatic aldehydes, as well as aliphatic aldehydes.
Parallel solution-phase synthesis of mechanism-based cysteine protease inhibitors
Lee, Alice,Ellman, Jonathan A.
, p. 3707 - 3709 (2007/10/03)
Figure presented A seven-step parallel solution-phase synthesis has been developed for access to ketone-containing mechanism-based cysteine protease inhibitors. The use of liquid-liquid extractions, volatile or solid-supported reagents, and resin-bound sc
