85451-85-0

Upstream product

• 534-13-4 N,N-dimethylthiourea 
• 74-88-4 methyl iodide 
• 74-87-3 methylene chloride 
• 6972-05-0 1,1-dimethyl-2-thiourea 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 97510-63-9 1-<(4-fluorophenyl)methyl>-2,3-dihydro-3-methyl-2-methyliminopyrido<2,3-d>pyrimidin-4-(1H)-one 
• 97510-85-5 1-(4-Fluoro-benzyl)-3-methyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione 

Relevant academic research and scientific papers

A facile route to cyclic and acyclic alkyl-arginines

Treatment of commercially available alkyl and cycloalkyl thioureas with methyl iodide provides the corresponding S-alkylisothiouronium iodide which reacts directly with ornithine to yield the title compounds.

AMINO 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists

This invention involves compounds having the following structure: as described in the Claims; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmaceutical compositions comprising such novel compounds. The invention also relates to the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.