854519-97-4

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Difluoro-1,2-benzenedimethanol is used as an intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory and anti-cancer properties. It aids in the development of drugs that can target and alleviate inflammation and cancerous conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4,5-Difluoro-1,2-benzenedimethanol is utilized as a building block in the creation of agrochemicals. Its synthesis contributes to the development of products that can enhance crop protection and improve agricultural yields.
Safety Precautions:
It is crucial to handle 4,5-Difluoro-1,2-benzenedimethanol with care, as it is classified as a hazardous substance. Direct contact with the skin and eyes can result in irritation. Proper protective measures should be taken during its use to minimize potential health risks.

Upstream product

• 18959-31-4 4,5-difluorophthalic acid 
• 18959-32-5 dimethyl 4,5-difluorophthalate 

Downstream Products

• 1092447-72-7 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester 
• 1092445-55-0 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid 
• 1092445-75-4 5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid 
• 1092445-74-3 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid 
• 1092447-92-1 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid ethyl ester 
• 1092445-77-6 5,6-difluoro-2-(3-methyl-2-propyl-benzoylamino)indan-2-carboxylic acid 
• 1092447-91-0 5,6-difluoro-2-(2-iodo-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester 
• 1092447-71-6 2-amino-5,6-difluoro-indan-2-carboxylic acid ethyl ester 
• 915944-27-3 1,2-bis(bromomethyl)-4,5-difluorobenzene 

Relevant academic research and scientific papers

COMBINATION THERAPY

The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2

INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, M, ?, n, p, and q are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.

INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, n and p are as defined herein

CHEMICAL COMPOUNDS AS ANTIBIOTICS

The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p? q, L, ?, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS

The present invention relates to A compound of the formula Ia wherein in any of its stereoisomers forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.

Indanyl-piperazine compounds

A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, ?or R1 represents a hydrogen atom, and R2 and R3 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, n represents 1 or 2, —X— represents a group selected from —(CH2)m—O-Ak-, —(CH2)m—NR4-Ak-, —(CO)—NR4-Ak- and —(CH2)m—NR4-(CO)—, ?m represents an integer between 1 and 6 inclusive, Ak represents an optionally substituted alkylene chain, and R4 represents a hydrogen atom or an alkyl group, Ar represents an aryl or heteroaryl group, its enantiomers, diasteroisomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.