85452-41-1

Upstream product

• 116452-89-2 1-ethoxycarbonylcyclopropanecarbonyl azide 
• 100-51-6 benzyl alcohol 
• 107259-05-2 1-tert-butoxycarbonylamino-cyclopropanecarboxylic Acid Ethyl Ester 
• 3697-67-4 ethyl 1-chlorocarbonylcyclopropanecarboxylate 
• 3697-66-3 1,1-cyclopropanedicarboxylic acid monoethyl ester 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 
• 42303-42-4 ethyl 1-aminocyclopropanecarboxylate hydrochloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 441784-97-0 benzyl 1-{[t-butyl(diphenylsilyl)oxy]methylcyclopropyl}(methyl)carbamate 
• 441786-55-6 benzyl 1-({[t-butyl(diphenyl)silyl]oxy}methyl)cyclopropylcarbamate 
• 1445884-18-3 C₁₅H₁₉NO₄ 
• 1445884-22-9 C₁₃H₁₈N₂O₂ 
• 1445884-21-8 C₂₁H₂₀N₂O₄ 
• 1445884-20-7 C₁₄H₁₉NO₅S 
• 1445884-19-4 C₁₃H₁₇NO₃ 
• 103500-24-9 ethyl (E)-3-<1-<(benzyloxycarbonyl)amino>cyclopropyl>-2-propenoate 
• 103500-25-0 (E)-3-<1-<(benzyloxycarbonyl)amino>cyclopropyl>-2-propenoic acid 
• 103500-23-8 1-<(benzyloxycarbonyl)amino>cyclopropanecarboxaldehyde 
• 103500-22-7 1-(Benzyloxycarbonylamino)cyclopropanemethanol 

Relevant academic research and scientific papers

Gold-Catalyzed Amide/Carbamate-Linked N, O-Acetal Formation with Bulky Amides and Alcohols

A gold-catalyzed N,O-acetal formation was established to construct an amide/carbamate-linked N,O-acetal substructure with bulky alcohols. The acyliminium cation species generated from o-alkynylbenzoic acid ester in the presence of a gold catalyst is highly reactive and underwent nucleophilic attack of various bulky alcohols and phenols at room temperature under neutral conditions, leading to the corresponding N,O-acetals in yields of 34-89% with good functional group tolerance.

NUCLEOSIDE PHOSPHONATE DERIVATIVES USEFUL IN THE TREATMENT OF HIV INFECTIONS

The present invention relates to a method of treating HIV infections by administering a nucleoside phosphonate derivative represented by formula (I).

Inactivation of γ-Aminobutyric Acid Aminotransferase by (S,E)-4-Amino-5-fluoropent-2-enoic Acid and Effect on the Enzyme of (E)-3-(1-Aminocyclopropyl)-2-propenoic Acid

(S,E)-4-Amino-5-fluoropent-2-enoic acid (6) is synthesized in six steps starting from the known γ-aminobutyric acid aminotransferase (γ-Abu-T) inactivator, (S)-4-amino-5-fluoropentanoic acid (1).Compound 6 is a mechanism-based inactivator of γ-Abu-T: time-dependent inactivation is saturable and protected by substrate; thiols do not protect the enzyme from inactivation; no enzyme activity returns upon dialysis.This compound (6) binds 50 times more tightly to γ-Abu-T than does the saturated analogue (1).No transamination of 6 occurs prior to inactivation.However, five molecules of 6 are required to inactivate the enzyme with concomitant release of five fluoride ions.Therefore, four molecules are being converted to product for each inactivation event. (E)-3-(1-Aminocyclopropyl)-2-propenoic acid is synthesized in seven steps from 1-aminocyclopropanecarboxylic acid.It is prepared as a cyclopropyl derivative of the proposed intermediate in the inactivation of γ-Abu-T by 6.The cyclopropyl derivative, however, is a noncompetitive inhibitor and does not inactivate the enzyme.This study shows the usefulness and hazards of incorporation of a trans double bond into potential γ-Abu-T inactivators.