3697-66-3

Basic information

• Product Name: 1-(ethoxycarbonyl)cyclopropanecarboxylic acid
• Synonyms: 1-(ethoxycarbonyl)cyclopropanecarboxylic acid;1,1-Cyclopropanedicarboxylic acid, 1-ethyl ester;2-METHYL-2-PROPANYL [(3R)-3-MORPHOLINYLMETHYL]CARBAMATE;1-(Ethoxycarbonyl)Cyclopropanecarboxylic Acid(WXC03382)
• CAS NO: 3697-66-3
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.1519
• Mol File: 3697-66-3.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 66-69℃ (0.15 Torr)
• Appearance: /
• Density: 1.339±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.46±0.20(Predicted)
• CAS DataBase Reference: 1-(ethoxycarbonyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(ethoxycarbonyl)cyclopropanecarboxylic acid(3697-66-3)
• EPA Substance Registry System: 1-(ethoxycarbonyl)cyclopropanecarboxylic acid(3697-66-3)

Safety Data

• Hazardous Substances Data: 3697-66-3(Hazardous Substances Data)

Usage

Uses

1-(Ethoxycarbonyl)cyclopropanecarboxylic Acid is used in preparation of broad-spectrum anticancer medicine cabozantinib.

Upstream product

• 64-17-5 ethanol 
• 34867-88-4 cyclopropane-1,1-dicarbonyl peroxide 
• 105-53-3 diethyl malonate 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 

Downstream Products

• 3697-68-5 ethyl 1-(hydroxymethyl)cyclopropanecarboxylate 
• 849217-68-1 cabozantinib 
• 849217-77-2 1-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamoyl)cyclopropane-1-carboxylic acid 
• 849217-51-2 N-[3-fluoro-4-[[7-benzyloxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 849217-50-1 N-[3-fluoro-4-[[7-hydroxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 116452-89-2 1-ethoxycarbonylcyclopropanecarbonyl azide 
• 85452-41-1 ethyl 1-<(benzyloxycarbonyl)amino>cyclopropanecarboxylate 
• 4606-07-9 ethyl cyclopropylcarboxylate 
• 139229-57-5 ethyl 1-(trifluoromethyl)cyclopropane-1-carboxylate 
• 42303-42-4 ethyl 1-aminocyclopropanecarboxylate hydrochloride 

Relevant articles and documents

Efficient method for removal of a carboxylic acid moiety from sterically crowded cyclopropanedicarboxylic acid derivatives

A versatile method was developed to the dealkoxycarbonylation of sterically crowded cyclopropanecarboxylic acid derivatives via a nonhydrolytic ester cleavage followed by a Barton-type decarboxylation.

SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II):