854529-01-4Relevant academic research and scientific papers
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity
Nallan, Laxman,Bauer, Kevin D.,Bendale, Pravin,Rivas, Kasey,Yokoyama, Kohei,Hornéy, Carolyn P.,Pendyala, Prakash Rao,Floyd, David,Lombardo, Louis J.,Williams, David K.,Hamilton, Andrew,Sebti, Said,Windsor, William T.,Weber, Patricia C.,Buckner, Frederick S.,Chakrabarti, Debopam,Gelb, Michael H.,Van Voorhis, Wesley C.
, p. 3704 - 3713 (2005)
New therapeutics to combat malaria are desperately needed. Here we show that the enzyme protein farnesyltransferase (PFT) from the malaria parasite Plasmodium falciparurn (P. falciparum) is an ideal drug target. PFT inhibitors (PFTIs) are well tolerated i
