854585-36-7

Upstream product

• 186393-18-0 ((S)-1-benzyl-2-cyano-2-hydroxy-ethyl)-carbamic acid tert-butyl ester 
• 191849-93-1 3(S)-(N-tert-butoxycarbonylamino)-2(R,S)-hydroxy-4-phenylbutyric acid 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 209173-80-8 2(RS)-hydroxy-3(S)-amino-4-phenylbutanoic acid 
• 72155-45-4 Boc-L-phenylalaninal 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 862388-11-2 ((1S)-1-benzyl-2-hydroxy-3-oxo-3-(propylamino)propyl)carbamic acid 1,1-dimethylethyl ester 

Relevant academic research and scientific papers

Significance of hydrogen bonding at the S1′ subsite of calpain I

α-Ketohydroxamates were synthesized as bioisosteres of α-ketoamides. The α-ketohydroxamates were generally more potent than the corresponding α-ketoamides. The potency of the compounds suggests that hydrogen bonding and steric bulk of substituents on the nitrogen atom of the ketoamide moiety influence calpain inhibition.