854602-02-1

Basic information

• Product Name: N-(3-nitro-benzyl)-p-toluidine
• Synonyms: N-(3-nitro-benzyl)-p-toluidine
• CAS NO: 854602-02-1
• Molecular Weight: 242.277
• Mol File: 854602-02-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(3-nitro-benzyl)-p-toluidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-nitro-benzyl)-p-toluidine(854602-02-1)
• EPA Substance Registry System: N-(3-nitro-benzyl)-p-toluidine(854602-02-1)

Safety Data

• Hazardous Substances Data: 854602-02-1(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 106-49-0 p-toluidine 
• 17064-95-8 N-(3-nitrobenzylidene)-4-methylbenzenamine 
• 619-23-8 3-Nitrobenzyl chloride 

Relevant articles and documents

Rhodium catalysts with cofactor mimics for the biomimetic reduction of CN bonds

A strategy based on the cooperation between metal and bonded cofactor mimics was applied to the transfer hydrogenation of CN bonds. We designed and synthesized a rhodium complex containing a 1,3-dimethylbenzoimidazole moiety, which could transfer hydride from a rhodium center to imine substrates in a biomimetic way. Under both transfer hydrogenation and reductive amination reaction conditions, the catalyst exhibited good selectivity towards CN bonds. With the catalyst, 34 imines were transfer hydrogenated to corresponding amines and a key intermediate of retigabine was prepared via reductive amination in a greener way. According to the NMR observations and isotope experiments, a plausible mechanism for this biomimetic reduction of CN bonds were proposed.

Solvent-free mechanochemical and one-pot reductive benzylizations of malononitrile and 4-methylaniline using Hantzsch 1,4-dihydropyridine as the reductantt

The properties of Hantzsch 1,4-dihydropyridine, which possesses excellent reducibility, were investigated. The synthesis of benzyl malononitriles and anilines were also studied. Direct reductive benzylizations of malononitrile and 4-methylaniline by aromatic aldehydes were achieved using a Hantzsch 1,4-dihydropyridine as the reductant. It was observed that there is no need for the separation of the in situ generated benzylidene malononitriles and p-tolylamines.