17064-95-8

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 106-49-0 p-toluidine 
• 619-25-0 3-Nitrobenzyl alcohol 

Downstream Products

• 1207463-79-3 1-(3-nitrophenyl)-1-(p-tolylamino)hexan-3-one 
• 1207463-78-2 1-(3-nitrophenyl)-1-(p-tolylamino)pentan-3-one 
• 1373546-95-2 4,4,6-trimethyl-2-(3-nitro-phenyl)-1,2,3,4-tetrahydro-quinoline 
• 1373546-97-4 3-(4,4,6-trimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamine 
• 1373545-80-2 pyridine-3-sulfonic acid N-[3-(4,4,6-trimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-amide 
• 1373545-78-8 ethanesulfonic acid N-[3-(4,4,6-trimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-amide 
• 1373545-76-6 N-[3-(4,4,6-trimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-methanesulfonamide 
• 1373545-74-4 4-methyl-N-[3-(4,4,6-trimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-benzenesulfonamide 
• 1373545-72-2 N-[3-(4,4,6-trimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-benzenesulfonamide 
• 1373545-70-0 3-fluoro-N-[3-(4,4,6-trimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-benzenesulfonamide 

Relevant academic research and scientific papers

A simple procedure for the synthesis of 4-aza-podophyllotoxin derivatives in water under microwave irradiation conditions

4-Aza-podophyllotoxin derivatives were synthesized via the three-component reaction of an aldehyde, an aromatic amine, and either tetronic acid or 1,3-indanedione in water under microwave irradiation conditions. This new protocol has the advantages of hig

Systematic studies on mechanochemical synthesis: Schiff bases from solid aromatic primary amines and aldehydes

A versatile and robust mechanochemical route to Aldehyde–Schiff base conversions has been established for a broad range of aldehydes via a simple cogrinding in mortar with a pestle under a solvent-free, as well as solvent-assisted, environment. The extent

FeCl3-Mediated One-Pot Cyclization–Aromatization of Anilines, Benzaldehydes, and Phenylacetylenes under Ball Milling: A New Alternative for the Synthesis of 2,4-Diphenylquinolines

A straightforward and efficient method has been developed for the solvent-free synthesis of 2,4-diphenylquinolines via a one-pot reaction of anilines, benzaldehydes, and phenylacetylenes promoted by FeCl3 under solvent-free mechanochemical ball

Ru Nanoparticles-Loaded Covalent Organic Framework for Solvent-Free One-Pot Tandem Reactions in Air

Condensation of benzene-1,3,5-tricarbohydrazide with benzene-1,4-dicarboxaldehyde generated a new covalent organic framework, COF-ASB (1), in which the organic units are held together via hydrazone linkage to form porous frameworks. COF-ASB (1) is highly crystalline and displays good chemical and thermal stability and is permanently porous. In addition, 1 can be an ideal support to load Ru nanoparticles (Ru NPs) to generate Ru@COF-ASB (2). The obtained composite material is able to highly promote one-pot tandem synthesis of imine products from benzyl alcohols and corresponding amines under solvent-free conditions in air.

Mechanochemical milling promoted solvent-free imino Diels-Alder reaction catalyzed by FeCl3: Diastereoselective synthesis of cis-2,4-diphenyl-1,2,3,4-tetrahydroquinolines

Under mechanochemical ball-milling at room temperature, FeCl3 promoted Diels-Alder cycloaddition of styrene with in situ generated N-aryl aldimines in the absence of any solvent afforded exclusively cis-2,4-diphenyltetrahydroquinolines in good to excellent yields within 90 minutes. The isolation work up just involves washing the resulting reaction mixture with water and recrystallization from EtOH-H2O. The advantages of high diastereoselectivity, short reaction time, free use of organic solvent, low cost, employment of cheap, easily available and nontoxic catalyst, and simple work-up procedure make this protocol a very efficient and green alternative to traditional methods for constructing these kinds of heterocyclic skeletons.

Chitosan: A highly efficient renewable and recoverable bio-polymer catalyst for the expeditious synthesis of α-amino nitriles and imines under mild conditions

Commercial chitosan-without any post-modification with active Bronsted or Lewis acid centers-was found to be a highly efficient renewable and recoverable bio-polymer catalyst for the rapid and convenient synthesis of α-amino nitriles or imines from aromatic aldehydes and amines under mild reaction conditions at room temperature in high to quantitative yields. The α-amino nitrile derivatives were prepared through the Strecker reaction using trimethylsilyl cyanide (TMSCN) and catalyzed by chitosan as a heterogeneous bifunctional organocatalyst.

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R1 to R7 have the significance given herein. The compounds are activators of AMP-activated protein kinase (AMPK) and are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.

TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R7 have the significance given in claim 1, can be used as a medicament.

An efficient three-component synthesis of homoallylic amines catalysed by MgI2 etherate

A three-component reaction of aldehydes, amines and allyltributylstannane was efficiently carried out to afford the corresponding homoallylic amine derivatives in the presence of 20 mol% of MgI2 etherate [(MgI 2?(OEt2)n] under mild and neutral reaction conditions in good to excellent yields.

Synthesis of β-aminoketones and construction of highly substituted 4-piperidones by mannich reaction induced by persistent radical cation salts

A Mannich reaction of imines and ketones induced by persistent radical cation salts was Investigated, and a series of Mannich bases, β-amlnoketones, were synthesized. A novel cyclization to form the 4-piperidone skeleton was achieved In a tandem process. The reaction can be rationalized as a radical cation process supported by various evidence.