85461-03-6Relevant academic research and scientific papers
Fused pyridine derivatives
-
Example 212, (2010/01/30)
The present provides a condensed pyridine compound (I) represented by the following formula: (wherein, R2represents ring A represents benzene ring, pyridine ring, thiophene ring or furan ring; and B represents its pharmaceutically acceptable salt or hydrates thereof, which is a clinically useful medicament having a serotonin antagonism, in particular, that for treating, ameliorating or preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.
Heterocyclic compouds
-
, (2008/06/13)
A compound of the general formula wherein: n is 0 or 1; M1 is an amino group; Q is an aromatic heterocyclic group containing a basic nitrogen atom; M2 is an imino group; L is a template group; and A is an acidic group, or an ester or amide derivative thereof, or a sulphonamide group; and pharmaceutically acceptable salts and pro-drugs thereof, for use in the treatment of a disease in which platelet aggregation mediated by the binding of adhesion molecules to GPIIb-IIIa is involved. Novel compounds are also disclosed.
Heterocyclic derivatives
-
, (2008/06/13)
Compounds of formula I STR1 and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R13, M2, X1, Z1, Z1a, X2 and A1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Novel intermediates are also disclosed.
Heterocyclic derivatives
-
, (2008/06/13)
Compounds of formula I STR1 and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R13, M2, X1, Z1, Z1a, X2 and A1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Intermediates are also disclosed.
PROSTANOIDS. XI. SYNTHESIS OF SOME o-INTERPHENYLENEOXA ANALOGS OF 11-DEOXYPROSTAGLANDIN E1
Tolstikov, G. A.,Miftakhov, M. S.,Adler, M. E.,Sidorov, N. N.
, p. 2082 - 2090 (2007/10/02)
By the condensation of 1-(2-oxoethyl)-2-methoxycarbonylmethoxybenzene and its p-F and p-Cl derivatives with 1-morpholinocyclopentene the corresponding 2-ethyl>-2-cyclopenten-1-ones were obtained.They were used for the synthesis of the butyl esters of (+/-)-11-deoxy-3-oxa-4,5-dinor-3,6-inter-(13E)-prostaglandins E1 and (+/-)-11-deoxy-3-oxa-4,5-dinor-3,6-inter(o-phenylene)-(13E)-prostaglandin E1 and also the methyl esters of 11-deoxy-3-oxa-4,5-dinor-3,6-inter-(4-chloro-o-phenylene)-(13E)-15-ketoprostenoic, 4,5,17,18,19,20-hexanor-11-deoxy-3,17-dioxa-3,6-inter-(4-chloro-o-phenylene)-16-(m-chlorophenoxy)-(13E)-15-ketoprostenoic, and 1-homo-17,18,19,20-tetranor-11-deoxy-16-(m-chlorophenoxy)-(3Z,13E)-15-ketoprostadienoic acids.
