85461-04-7Relevant articles and documents
PROSTANOIDS. XI. SYNTHESIS OF SOME o-INTERPHENYLENEOXA ANALOGS OF 11-DEOXYPROSTAGLANDIN E1
Tolstikov, G. A.,Miftakhov, M. S.,Adler, M. E.,Sidorov, N. N.
, p. 2082 - 2090 (2007/10/02)
By the condensation of 1-(2-oxoethyl)-2-methoxycarbonylmethoxybenzene and its p-F and p-Cl derivatives with 1-morpholinocyclopentene the corresponding 2-ethyl>-2-cyclopenten-1-ones were obtained.They were used for the synthesis of the butyl esters of (+/-)-11-deoxy-3-oxa-4,5-dinor-3,6-inter-(13E)-prostaglandins E1 and (+/-)-11-deoxy-3-oxa-4,5-dinor-3,6-inter(o-phenylene)-(13E)-prostaglandin E1 and also the methyl esters of 11-deoxy-3-oxa-4,5-dinor-3,6-inter-(4-chloro-o-phenylene)-(13E)-15-ketoprostenoic, 4,5,17,18,19,20-hexanor-11-deoxy-3,17-dioxa-3,6-inter-(4-chloro-o-phenylene)-16-(m-chlorophenoxy)-(13E)-15-ketoprostenoic, and 1-homo-17,18,19,20-tetranor-11-deoxy-16-(m-chlorophenoxy)-(3Z,13E)-15-ketoprostadienoic acids.