85462-59-5

Usage

Uses

Used in Chemical Synthesis:
2-Bromo-5-chloro-4-fluoroaniline is utilized as a key intermediate in various chemical reactions, serving as a building block for the synthesis of more complex organic compounds. Its unique combination of halogens allows for selective reactions and functional group transformations, making it a versatile component in organic chemistry.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-Bromo-5-chloro-4-fluoroaniline is employed as a precursor for the development of new drugs. Its structural features enable the creation of molecules with specific biological activities, contributing to the discovery and production of medications for various therapeutic areas.
Used in Agrochemical Formulation:
2-Bromo-5-chloro-4-fluoroaniline also finds application in the agrochemical sector, where it is used in the synthesis of active ingredients for pesticides and herbicides. Its halogenated structure can impart properties such as increased stability and targeted biological activity, which are beneficial in agricultural chemical products.

InChI:InChI=1/C6H4BrClFN/c7-3-1-5(9)4(8)2-6(3)10/h1-2H,10H2

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 868408-85-9 6-(2-bromo-5-chloro-4-fluoro-phenyl)-4,6-diaza-spiro[2.4]heptane-5,7-dione 
• 1015427-16-3 2-amino-4-chloro-5-fluorobenzonitrile 
• 937816-87-0 1-(2-amino-4-chloro-5-fluorophenyl)ethanone 
• 231297-42-0 methyl (2E)-3-{4-chloro-5-fluoro-2-[(phenylsulfonyl)amino]phenyl}acrylate 
• 231297-40-8 methyl (2E)-3-(2-amino-4-chloro-5-fluorophenyl)acrylate 
• 916799-45-6 N,N-di-tert-butyloxycarbonyl-2-bromo-5-chloro-4-fluoro-aniline 
• 122509-72-2 6-Chloro-5-fluoro-1H-indole 
• 496916-77-9 3-chloro-4-fluoro-6-vinylaniline 

Relevant academic research and scientific papers

FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY

The present invention provides a compound of formula (I), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity,

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.

Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug

Cyclooxygenase (COX) is a key rate-limiting enzyme for prostaglandin (PG) production cascades in the human body. The mechanisms of both the anti-inflammation effects and the side-effects of traditional COX inhibitors are associated with the existence of two COX isoforms. Thus while COX-1 is predominantly expressed ubiquitously and constitutively, and it serves a housekeeping role in processes such as gastrointestinal (GI) mucosa protection, COX-2 is absent or exhibits a low level of expression in most tissues, and is highly upregulated in response to endotoxin, virus, inflammatory or tissue-injury stimuli/signals, and tumour promoter in the various types of organs, tissues, and cells. Furthermore, COX-2 contribution to PGE2 and PGI2 production evokes and sustains systemic or peripheral inflammatory disease, but it is not involved in the COX-1-mediated GI tract events. Also, hypersensitivity of aspirin owing to its inhibitory action against COX-1 is a significant concern clinically. Consequently, highly selective COX-2 inhibitors have been needed for the treatment of inflammatory- and inflammation related-diseases that include pyrexia, inflammation, pain, rheumatoid arthritis, osteoarthritis, and cancers. In this study, a series of novel [2-{[(4-substituted or 4,5-disubstituted)-pyridin-2-yl]carbonyl}-(5- or 6-substituted or 5,6-disubstituted)-1H-indol-3-yl]acetic acid analogues was designed, synthesized, and evaluated to identify potent and selective COX-2 inhibitors as potential agents against inflammatory diseases. As significant findings, the present study clarified unique structure-activity relationship of the analogues toward potent and selective COX-2 inhibition in vitro, and identified 2-{6-fluoro-2-[4-methyl-2-pridinyl)carbonyl]-1H-indol-3-yl}acetic acid as a potent and selective COX-2 inhibitor in vitro that demonstrated orally potent anti-inflammation efficacy against carrageenan-induced oedema formation in the foot of SPF/VAF male SD rats as a peripheral inflammation model in vivo.

1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is i

Preparation of 6-chloro-5-fluoroindole via the use of palladium and copper-mediated heterocyclisations

The title indole, the heterocyclic core of the 5-HT2C receptor agonist Ro 60-0175, was prepared by a modification to the Stille indole synthesis, or by the method of Gonzalez and co-workers.