854635-21-5Relevant articles and documents
Substituent activity relationship studies on new azolo benzoxazepinyl oxazolidinones
Das, Jagattaran,Sitaram Kumar,Subrahmanyam,Sastry,Prasad Narasimhulu,Laxman Rao,Kannan,Roshaiah,Awasthi, Riti,Patil, Santosh N.,Sarnaik,Rao Mamidi,Selvakumar,Iqbal, Javed
, p. 8032 - 8042 (2006)
In an effort to discover potent antibacterials based on the entropically favored 'bioactive conformation' approach, a series of novel tricyclic molecules mimicking the conformationally constrained structure of Linezolid is reported. Based on the initial tricyclic molecule 1, the benzazepine derivative 2 was designed where the tricyclic structure had more flexibility around C-N bond compared to 1. While, the molecule 2 was less active, the molecule 3 showed promising antibacterial activity presumably after having obtained rigidity due to pyrrole ring. The syntheses, SAR studies, and evaluation of 3 as a lead compound are reported.