854635-52-2

Basic information

• Product Name: [2-(2-hydroxymethyl-pyrrol-1-yl)-5-nitro-phenyl]-methanol
• Synonyms: [2-(2-hydroxymethyl-pyrrol-1-yl)-5-nitro-phenyl]-methanol
• CAS NO: 854635-52-2
• Molecular Weight: 248.238
• Mol File: 854635-52-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [2-(2-hydroxymethyl-pyrrol-1-yl)-5-nitro-phenyl]-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(2-hydroxymethyl-pyrrol-1-yl)-5-nitro-phenyl]-methanol(854635-52-2)
• EPA Substance Registry System: [2-(2-hydroxymethyl-pyrrol-1-yl)-5-nitro-phenyl]-methanol(854635-52-2)

Safety Data

• Hazardous Substances Data: 854635-52-2(Hazardous Substances Data)

Upstream product

• 854635-21-5 methyl 2-(2-formylpyrrol-1-yl)-5-nitrobenzoate 
• 217490-11-4 methyl 5-nitro-2-pyrrol-1-ylbenzoate 
• 4693-02-1 6-nitroisatoic anhydride 
• 3816-62-4 5-nitroanthranilic acid methyl ester 
• 118-48-9 isatoic anhydride 

Downstream Products

• 854635-68-0 benzyl (4H,6H-5-oxa-10b-azabenzo[e]azulen-8-yl)carbamate 

Relevant articles and documents

Substituent activity relationship studies on new azolo benzoxazepinyl oxazolidinones

In an effort to discover potent antibacterials based on the entropically favored 'bioactive conformation' approach, a series of novel tricyclic molecules mimicking the conformationally constrained structure of Linezolid is reported. Based on the initial tricyclic molecule 1, the benzazepine derivative 2 was designed where the tricyclic structure had more flexibility around C-N bond compared to 1. While, the molecule 2 was less active, the molecule 3 showed promising antibacterial activity presumably after having obtained rigidity due to pyrrole ring. The syntheses, SAR studies, and evaluation of 3 as a lead compound are reported.