85466-33-7Relevant academic research and scientific papers
2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV
Haffner, Curt D.,McDougald, Darryl L.,Reister, Steven M.,Thompson, Brian D.,Conlee, Christopher,Fang, Jing,Bass, Jonathan,Lenhard, James M.,Croom, Dallas,Secosky-Chang, Melissa B.,Tomaszek, Thaddeus,McConn, Donavon,Wells-Knecht, Kevin,Johnson, Paul R.
, p. 5257 - 5261 (2005)
We report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very long duration of action in both rat and dog.
RADIO-AND CHEMO-PROTECTIVE COMPOUNDS
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Paragraph 0327, (2021/11/13)
The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-l-thiol. Their use as radio- and chemo-protectors is also described.
