854765-42-7Relevant articles and documents
Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis
Hu, Baihua,Collini, Michael,Unwalla, Rayomand,Miller, Christopher,Singhaus, Robert,Quinet, Elaine,Savio, Dawn,Halpern, Anita,Basso, Michael,Keith, James,Clerin, Valerie,Chen, Liang,Resmini, Christine,Liu, Qiang-Yuan,Feingold, Irene,Huselton, Christine,Azam, Farooq,Farnegardh, Mathias,Enroth, Cristofer,Bonn, Tomas,Goos-Nilsson, Annika,Wilhelmsson, Anna,Nambi, Ponnal,Wrobel, Jay
, p. 6151 - 6154 (2007/10/03)
A structure-based approach was used to optimize our new class of quinoline LXR modulators leading to phenyl acetic acid substituted quinolines 15 and 16. Both compounds displayed good binding affinity for LXRβ and LXRα and were potent activators in LBD tr