854777-97-2

Upstream product

• 88-17-5 2-(trifluoromethyl)benzenamine 
• 39973-76-7 ethyl 2-benzoyl-3-ethoxyacrylate 

Downstream Products

• 854766-06-6 (4-{[{3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}(methyl)amino]methyl}phenyl)acetic acid 
• 854766-05-5 {4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid 
• 854778-03-3 methyl {4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetate 
• 854765-94-9 [4-({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy}methyl)phenyl]acetic acid 
• 912553-39-0 4-[3-(3-benzoyl-8-trifluoromethyl-quinolin-4-yl)-phenoxymethyl]-benzoic acid methyl ester 
• 854766-38-4 WAY-254011 
• 854777-99-4 3-benzoyl-8-(trifluoromethyl)quinolin-4-yl trifluoromethanesulfonate 
• 854766-61-3 3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]benzaldehyde 
• 854765-99-4 [4-(3-aminophenyl)-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone 
• 854765-81-4 [4-(3-hydroxyphenyl)-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone 
• 854765-42-7 [4-(4-hydroxyphenyl)-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone 
• 854777-89-2 [4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone 
• 854777-98-3 (4-hydroxy-8-trifluoromethyl-quinolin-3-yl)phenylmethanone 

Relevant academic research and scientific papers

Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis

A structure-based approach was used to optimize our new class of quinoline LXR modulators leading to phenyl acetic acid substituted quinolines 15 and 16. Both compounds displayed good binding affinity for LXRβ and LXRα and were potent activators in LBD tr

QUINOLINE COMPOUNDS

To provide a novel LXRbeta agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A quinoline compound represented by the following general formula (1) or salt thereof, or their solvate

Quinolines useful in treating cardiovascular disease

This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.