85482-36-6Relevant academic research and scientific papers
ALDOSTERONE SYNTHASE INHIBITORS
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Page/Page column 88, (2012/02/05)
The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
SYNTHESIS OF 2,1-BENZISOTHIAZOLINE 2,2-DIOXIDE DERIVATIVES
Wojciechowski, K.
, p. 1121 - 1124 (2007/10/02)
Base-induced (NaOH/DMSO) intramolecular SNAr of fluorine in methanesulfonanilide 1 derivatives leads to 6-nitro-2,1-benzisothiazoline derivatives 2. meta-Nitro methanesulfonanilides 3 in the presence of tert-BuOK in DMF were transformed into 4-
