85485-60-5

Usage

Structure

Pyrazole derivative with a methyl group and a phenyl group attached to the pyrazole ring

Pharmacological activities

Potential antiviral, antibacterial, and anti-inflammatory properties

Use in organic synthesis

Building block for the preparation of other complex compounds

Research interest

Potential applications in drug discovery and development

Upstream product

• 19521-13-2 α,β-dibromo-β-phenylpropionitrile 
• 60-34-4 methylhydrazine 
• 98-86-2 acetophenone 
• 78583-84-3 (Z)-3-chloro-3-phenyl-2-propenenitrile 
• 1885-38-7 cinnamic nitrile 

Downstream Products

• 92133-84-1 4-Methyl-N-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-benzenesulfonamide 

Relevant academic research and scientific papers

CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Aminopyrazoles. IV. Pyrazol-3- and 5-amines from 2,3-dihaloalkanenitriles or 3-Chloroacrylonitriles and Hydrazines

2,3-Dihalopropanenitriles and substituted 3-chloropropenenitriles react with hydrazines in basic solution to form either pyrazol-3-amines 4 or pyrazol-5-amines 5 or a mixture of both isomers.