85503-13-5Relevant academic research and scientific papers
A process for the synthesis of βketoesters using in-situ generated (trimethylsilyl)malonates
Wang, Xui,Monte, William T.,Napier, James J.,Ghannam, Ameen
, p. 9323 - 9326 (2007/10/02)
(TMS)ethyl malonate can be generated in-situ by treating potassium ethyl malonate with trimethylsilyl chloride and acylated with aliphatic or aromatic acyl imidazoles or chlorides in the presence of DBU to prepare a variety of β-ketoesters. This constitutes a high yield method for preparing β-ketoesters, which also can be extended to the formation of alkylidene malonates.
N-[4-(3-aminopropyl)-aminobutyl]-2-(ω-guanidino-fatty-acid-amido)-2-substituted-ethanamide and salt thereof
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, (2008/06/13)
N-[4-(3-Aminopropyl)aminobutyl]-2-(ω-guanidino-fatty acid-amido)-2-substituted-ethanamides represented by the general formula STR1 wherein Y represents --(CH2 --CH2 --, --CH=CH or STR2 R represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms which may have a hydroxyl group as substituent, or a benzyl group, and n is an integer of from 1 to 8, provided that when Y is STR3 and n is 4, R represents the groups other than the hydrogen atom; a salt thereof having antitumor activity in experimental animal tumors and a process for the preparation thereof is provided.
