161012-51-7Relevant academic research and scientific papers
A process for the synthesis of βketoesters using in-situ generated (trimethylsilyl)malonates
Wang, Xui,Monte, William T.,Napier, James J.,Ghannam, Ameen
, p. 9323 - 9326 (1994)
(TMS)ethyl malonate can be generated in-situ by treating potassium ethyl malonate with trimethylsilyl chloride and acylated with aliphatic or aromatic acyl imidazoles or chlorides in the presence of DBU to prepare a variety of β-ketoesters. This constitutes a high yield method for preparing β-ketoesters, which also can be extended to the formation of alkylidene malonates.
An enantioselective synthesis of differentially protected erythro-α,β-diamino acids and its application to the synthesis of an analogue of rhodopeptin B5
Durham, Timothy B.,Miller, Marvin J.
, p. 35 - 42 (2007/10/03)
Methodology for the enantioselective synthesis of differentially protected erythro-α,β-diamino acids from N-tosyloxy β-lactams is reported. The requisite N-tosyloxy β-lactams are readily available from simple β-keto esters. The reported approach is flexible and compatible with a variety of functional groups. The synthetic utility of the method is demonstrated through its application to the preparation of an analogue of the antifungal cyclic peptide rhodopeptin B5.
Synthesis of philanthotoxin analogs with bulky heads including porphyrins. Self-assembly monitored by circular dichroism
Huang, Danwen,Matile, Stefan,Berova, Nina,Nakanishi, Koji
, p. 723 - 736 (2007/10/03)
Philanthotoxin (PhTX) analogs with bulky bis-iminodibenzyl and porphyrin head groups have been prepared. Exciton coupled CD studies show that dependent on the hydrophobicity of the head group PhTX analogs may get amphiphilic properties forming micelles in
