85522-02-7Relevant academic research and scientific papers
Reductive Alkylation of Amines with Carboxylic Ortho Esters
Kadyrov, Renat,Moebus, Konrad
, p. 3352 - 3357 (2020)
We have demonstrated for the first time that carboxylic ortho esters could be used as an alkylating agent in the reductive alkylation of amines. A variety of amines, including amino acid esters, were alkylated affording mono-alkylated products with high selectivity in practical to high yields using standard heterogeneous catalysts. By applying acyclic ortho esters alkylation was completed at room temperature. (Figure presented.).
