855290-50-5

Upstream product

• 98-10-2 benzenesulfonamide 
• 99186-88-6 4-Propylsulfonyl-benzoesaeure 
• 15898-42-7 sodium 4-cyanobenzenesulfinate 
• 106-94-5 propyl bromide 
• 1194-02-1 4-fluorobenzonitrile 
• 855196-51-9 4-(propylthio)benzonitrile 
• 90926-25-3 1-(4-tolylsulfonyl)propane 
• 855290-98-1 4-(prop-2-ene-1-sulfonyl)-benzonitrile 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 84264-88-0 4-(propane-1-sulfonyl)-benzaldehyde 

Relevant academic research and scientific papers

BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF ROR-GAMMA

Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

THERAPEUTIC AGENTS

A compound of the formula (I): wherein R1,R2,R3, R4,Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medicine, for example in the treatment of schizophrenia.