855301-93-8

Upstream product

• 6940-76-7 1-iodo-3-chloro-propane 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 

Downstream Products

• 151746-70-2 (R)-2-((2S,6R)-8-Benzyl-2-pentyl-1,8-diaza-spiro[5.5]undec-1-yl)-2-phenyl-ethanol 
• 151850-98-5 (R)-2-((2R,6R)-8-Benzyl-2-pentyl-1,8-diaza-spiro[5.5]undec-1-yl)-2-phenyl-ethanol 
• 855310-82-6 (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propan-1-ol 
• 855310-79-1 [(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile 
• 855310-80-4 (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionitrile 
• 855310-81-5 (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde 
• 855310-77-9 {(5S,7S)-6-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-1-[1-cyano-meth-(E)-ylidene]-6-aza-spiro[4.5]dec-7-yl}-acetic acid ethyl ester 
• 855310-78-0 [(5S,7S)-6-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-7-(2-hydroxy-ethyl)-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile 
• 855310-75-7 [(5S,7S)-1-[1-Cyano-meth-(E)-ylidene]-6-((R)-2-hydroxy-1-phenyl-ethyl)-6-aza-spiro[4.5]dec-7-yl]-acetic acid ethyl ester 
• 855310-73-5 C₁₉H₂₂N₂O 
• 855310-69-9 C₁₇H₂₁NO₂ 
• 855301-96-1 3a-amino-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile 
• 855302-03-3 3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile 
• 855301-94-9 6-phenyl-2,3,5,6,9,10-hexahydro-1H-4-oxa-6a-azacyclopenta[d]naphthalen-3a-ylamine 

Relevant academic research and scientific papers

Asymmetric Synthesis. XXXIV. Synthesis of Spiro-Piperidine Derivatives via the CN(R,S) Method.

Key-words: Asymmetric synthesis; spiro-piperidine; 5-azaspiro nonane, 6-azaspiro- decane. - Abstract: 5-Aza-spiro- nonane and 6-aza-spiro- decane derivatives 5 and 9 have been prepared from 2-cyano-6-phenyloxazolopiperidine synthon 2b via alkylation followed by cyclisation of the resulting halogeno aminonitrile under dissolving metal conditions.

A diastereoselective approach for an asymmetric synthesis in pinnaic acid series

An enantiopure spiran-bearing advanced intermediate in pinnaic acid series was obtained in 11 steps starting with CN(R,S) building block.

Diasteroselective synthesis of new spiropiperidine scaffolds from the CN(R,S) building block

A methodology allowing the construction of spiropiperidine scaffolds similar to those found in naturally occurring alkaloids has been developed. This approach begins with the well-established CN(R,S) strategy, the spiro-center being built by way of an int