855316-57-3

Upstream product

• 440370-41-2 4-(R)-(3,4-difluorophenyl)-4-{N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylcarbamoyl}-3-(R)-(4-methoxyphenoxymethyl)butyric acid methyl ester 
• 96821-35-1 (E)-4-(4-methoxy-phenoxy)-but-2-enoic acid methyl ester 
• 121639-61-0 3,4-difluorophenylacetyl chloride 
• 440370-30-9 (1R,2R)-2-(3,4-difluorophenyl)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl acetamide 
• 150-76-5 4-methoxy-phenol 
• 658-93-5 (3,4-difluorophenyl)acetic acid 

Downstream Products

• 440370-50-3 3-(R)-(3,4-difluorophenyl)-4-(R)-(4-methoxyphenoxymethyl)tetrahydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Synthesis of a tetrahydropyran NK1 receptor antagonist via asymmetric conjugate addition

Two asymmetric syntheses of the NK1 receptor antagonist 1-[2-(R)-{1-(R)-[3,5-bis(trifluoromethyl)-phenyl]ethoxy}-3-(R)-(3, 4-difluorophenyl)-4-(R)-tetrahydro-2H-pyran-4-ylmethyl]-3-(R) -methylpiperidine-3-carboxylic acid (1) were developed. In

Pseudoephedrine as a chiral auxiliary for asymmetric Michael reactions: synthesis of 3-aryl-delta-lactones.

[reaction: see text] The asymmetric Michael reaction of pseudoephedrine amides is reported. The 1,5-dicarbonyl products are converted to 3-aryl-delta-lactones in a two-step reduction/lactonization sequence. This method provides access to enantiomerically enriched trans-3,4-disubstituted delta-lactones.