855388-58-8

Upstream product

• 13664-92-1 2,2-dibromo-1-(4-methoxyphenyl)ethanone 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 418774-59-1 (2-Benzo[1,3]dioxol-5-yl-ethyl)-(4-methoxy-benzyl)-amine 

Relevant academic research and scientific papers

Synthesis of isoquinoline alkaloids via oxidative amidation-bischler- napieralski reaction

A straightforward synthesis of -keto amides by coupling primary amines with aryl dibromoethanones under oxidative amidation conditions has been developed. The -keto amides were then subjected to heterocyclodehydration reaction under Bischler-Napieralski conditions followed by aromatization with DBU provided 1-benzoyl isoquinolines in a two-stage process. Utilizing this methodology, isoquinoline alkaloids such as thalmicrinone, papavaraldine, and pulcheotine A were synthesized in excellent yields. Georg Thieme Verlag Stuttgart · New York.

Synthesis and antihyperglycemic evaluation of various protoberberine derivatives

Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.