855399-86-9Relevant academic research and scientific papers
SUBSTITUTED TROPOLONE DERIVATIVES AND METHODS OF USE
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Page/Page column 18, (2014/01/09)
The compositions and methods described herein relate generally to substituted tropolone derivatives, which, among other features, are useful as histone deacetylase (HDAC) inhibitors.
Tropolones as lead-like natural products: The development of potent and selective histone deacetylase inhibitors
Ononye, Sophia N.,Vanheyst, Michael D.,Oblak, E. Zachary,Zhou, Wangda,Ammar, Mohamed,Anderson, Amy C.,Wright, Dennis L.
, p. 757 - 761 (2013/09/02)
Natural products have long been recognized as a rich source of potent therapeutics but further development is often limited by high structural complexity and high molecular weight. In contrast, at the core of the thujaplicins is a lead-like tropolone scaf
